Description

3,3',5-Triiodo-L-Thyronine is a high-purity iodinated amino acid derivative, also known as Liothyronine or T3. This compound is a critical active pharmaceutical ingredient (API) and a vital biochemical standard for research and diagnostic applications. It is essential for manufacturers in the pharmaceutical, biotechnology, and life science research sectors requiring a reliable, high-quality source for hormone replacement therapies, metabolic studies, and assay development.

Application

• Pharmaceutical API: Core active ingredient in the formulation of Liothyronine Sodium, used for thyroid hormone replacement therapy.
• Biochemical Research: Essential standard and reagent in metabolic pathway studies, endocrine research, and receptor binding assays.
• Diagnostic Manufacturing: Key component in the production of calibration standards and controls for in-vitro diagnostic (IVD) kits measuring thyroid function.
• Reference Standard: High-purity material for use as a primary reference standard in quality control laboratories for pharmacopeial (e.g., USP, EP) testing.
• Veterinary Pharmaceuticals: Used in formulations for treating hypothyroidism in animals.

Basic Information

Product Name	3,3',5-Triiodo-L-Thyronine
CAS No.	6893-02-3
Molecular Formula	C15H12I3NO4
Molecular Weight	650.97 g/mol
Synonyms	Liothyronine; T3; L-Triiodothyronine; 3,3',5-Triiodothyronine; (2S)-2-Amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic Acid; Thyronine, 3,3',5-triiodo-; Triiodothyronine; O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine
EINECS	229-999-3

Quality Control

Our 3,3',5-Triiodo-L-Thyronine is manufactured under strict quality systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets stringent specifications suitable for pharmaceutical and research use. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific pharmacopeial standards (USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to minimize exposure to air and humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Specific Rotation	+18° to +22° (c=1 in 1N HCl-Ethanol)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.