Description

1,2-Cyclopropanedicarbonyl Dichloride, (1R,2R)-Rel- (9Ci) CAS NO 6860-35-1 is a high-purity, chiral building block characterized by its strained cyclopropane ring and reactive acid chloride functionalities. This compound is critically important for the synthesis of complex, stereochemically defined molecules, particularly in advanced pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) with specific stereochemistry, particularly in antiviral, anticancer, and CNS drug candidates.
• Agrochemical Synthesis: Used in the production of advanced, enantiomerically pure herbicides, fungicides, and insecticides where the specific spatial orientation of the molecule impacts biological activity.
• Ligand and Catalyst Precursor: Serves as a starting material for the preparation of chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetic and Proline Analog Development: The cyclopropane structure is a valuable rigid scaffold in medicinal chemistry for creating conformationally restricted peptide analogs and novel amino acid derivatives.
• Material Science Research: Employed in the development of specialty polymers and advanced materials with unique structural properties derived from the cyclopropane unit.
• Chemical Biology Probes: Useful for the synthesis of molecular probes and tags designed to study biological systems and enzyme mechanisms.

Basic Information

Product Name	1,2-Cyclopropanedicarbonyl Dichloride, (1R,2R)-Rel- (9Ci)
CAS No.	6860-35-1
Molecular Formula	C5H4Cl2O2
Molecular Weight	166.99 g/mol
Synonyms	(1R,2R)-1,2-Cyclopropanedicarbonyl Dichloride; (1R,2R)-Cyclopropane-1,2-dicarbonyl Dichloride; (1R,2R)-Rel-1,2-Cyclopropanedicarboxylic Acid Dichloride; (1R,2R)-1,2-Cyclopropanedicarboxylic Acid Dichloride; (1R,2R)-Cyclopropane-1,2-dicarboxylic Acid Dichloride; (1R,2R)-1,2-Bis(chlorocarbonyl)cyclopropane; (1R,2R)-Cyclopropane-1,2-dicarbonyl Chloride
EINECS	Contact for details

Quality Control

Our 1,2-Cyclopropanedicarbonyl Dichloride, (1R,2R)-Rel- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure high enantiomeric excess (ee) and chemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and reactive acid chloride nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C for long-term stability. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.