Description

4-Dehydrowithaferin A is a specialized, high-purity steroidal lactone derived from the Withania somnifera plant, representing a key intermediate and reference standard in advanced phytochemical research. This compound matters for its significant role in the study of bioactive withanolides, offering researchers a precise tool for investigating structure-activity relationships and metabolic pathways. It is primarily needed by pharmaceutical R&D laboratories, nutraceutical developers, and academic institutions focused on oncology, neuropharmacology, and natural product chemistry.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for the qualitative and quantitative analysis of withanolide content in raw materials and finished products.
• Bioactivity Research: Serves as a critical intermediate in studies exploring the anti-inflammatory, anti-tumor, and immunomodulatory properties of withanolide derivatives.
• Natural Product Isolation & Synthesis: Acts as a marker compound for the standardization of Ashwagandha (Withania somnifera) extracts and as a starting material for the semi-synthesis of novel analogs.
• Analytical Method Development: Employed in developing and validating HPLC, LC-MS, and TLC methods for the fingerprinting and quality control of herbal preparations.
• Preclinical Studies: Utilized in in-vitro and in-vivo models to elucidate mechanisms of action and pharmacokinetic profiles of withanolide-based therapeutics.

Basic Information

Product Name	4-Dehydrowithaferin A
CAS No.	6850-30-2
Molecular Formula	C28H36O7
Molecular Weight	484.58 g/mol
Synonyms	4-Dehydro-27-hydroxywithaferin A; 4-Dehydro-27-hydroxy-5β,6β-epoxy-1-oxo-22R-witha-2,24-dienolide; Withaferin A derivative; 4-Dehydro-27-hydroxywithanolide A; 4-Dehydro-27-hydroxy-5β,6β-epoxy-1-oxowitha-2,24-dienolide; 4-Dehydro-27-hydroxywithaferin A; 4-Dehydro-27-hydroxy-5β,6β-epoxy-1-oxo-22R-witha-2,24-dienolide
EINECS	Contact for details

Quality Control

Our 4-Dehydrowithaferin A is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While not intended for human consumption as a raw material, its production adheres to principles of good laboratory practice (GLP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.