Description

1,2-Cyclopropanedicarbonyl Dichloride, (1R-Trans)- (9Ci) is a high-purity, chiral building block of significant interest in advanced organic synthesis. Its value lies in the rigid, strained cyclopropane ring and reactive acid chloride functionalities, which enable the stereoselective construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, enzyme modulators, and other biologically active molecules requiring a defined stereochemistry.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand and Catalyst Preparation: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with unique structural properties.
• Peptide Mimetics: The cyclopropane scaffold is used to create conformationally restricted peptide analogs for drug discovery.

Basic Information

Product Name	1,2-Cyclopropanedicarbonyl Dichloride, (1R-Trans)- (9Ci)
CAS No.	6820-59-3
Molecular Formula	C5H4Cl2O2
Molecular Weight	166.99 g/mol
Synonyms	(1R,2R)-1,2-Cyclopropanedicarbonyl dichloride; (1R,2R)-Cyclopropane-1,2-dicarbonyl dichloride; trans-1,2-Cyclopropanedicarboxylic acid dichloride; (1R,2R)-1,2-Cyclopropanedicarboxylic Acid Dichloride; (1R-trans)-Cyclopropane-1,2-dicarbonyl Chloride; (1R,2R)-Dichlorocarbonylcyclopropane
EINECS	Contact for details

Quality Control

Every batch of our 1,2-Cyclopropanedicarbonyl Dichloride is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as chiral purity, chemical purity, and impurity profiles. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) requirements for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and reacts vigorously with water, strong bases, and alcohols. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.