Description

Tms-Glycerol is a trimethylsilyl-protected derivative of glycerol, a key reagent in organic synthesis and analytical chemistry. Its primary value lies in its ability to protect hydroxyl groups, enabling selective reactions and facilitating the analysis of complex molecules like sugars and lipids. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries who require precise chemical modification and characterization. Its moisture-sensitive nature necessitates careful handling to maintain purity and reactivity.

Application

• Pharmaceutical Synthesis: Used as a protecting group for hydroxyl functionalities during the multi-step synthesis of active pharmaceutical ingredients (APIs) and complex drug molecules.
• Analytical Chemistry: Employed as a derivatization agent in Gas Chromatography (GC) and Gas Chromatography-Mass Spectrometry (GC-MS) for the analysis of polar compounds like carbohydrates, steroids, and alcohols to improve their volatility and detection.
• Biochemical Research: Serves as a crucial reagent in the study and modification of lipids, glycans, and other biomolecules, aiding in structure elucidation and metabolic pathway analysis.
• Fine Chemical Production: Acts as an intermediate in the synthesis of specialty chemicals, silicone-based compounds, and advanced materials where selective protection is required.
• Polymer Science: Utilized in the development and modification of polymers, where it can introduce silyl groups to alter material properties such as solubility and stability.

Basic Information

Product Name	Tms-Glycerol
CAS No.	6787-10-6
Molecular Formula	C9H24O3Si3
Molecular Weight	264.54 g/mol
Synonyms	1,2,3-Tris(trimethylsilyloxy)propane; Glycerol tris(trimethylsilyl) ether; Tris(trimethylsilyl) glycerol; Glycerin tris(trimethylsilyl ether); Tris-O-(trimethylsilyl)glycerol; TMS-Glycerol; Glycerol TMS derivative; Propane-1,2,3-triyl tris(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Our Tms-Glycerol is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including assay by GC or HPLC, identity confirmation by IR or NMR, and impurity profiling to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.