Description

Phthalylglycyl Chloride is a key acyl chloride intermediate used in the synthesis of complex organic molecules. Its high reactivity makes it a valuable reagent for introducing the phthalylglycyl moiety, enabling the construction of peptide-like structures and other pharmacologically active compounds. This product is essential for research and development laboratories, as well as production facilities in the pharmaceutical and fine chemical industries, where precise molecular assembly is critical.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring a protected glycine derivative.
• Peptide Chemistry: Used as an acylating agent for the introduction of the N-phthalylglycyl group in peptide coupling reactions and solid-phase peptide synthesis.
• Protecting Group Chemistry: Serves as a reagent for installing the phthaloyl protecting group on amino functions, which is stable under various reaction conditions and can be selectively removed.
• Fine Chemical Synthesis: Employed in the production of specialty chemicals, dyes, and advanced materials that require specific acyl chloride functionalities.
• Bioconjugation: Useful in modifying biomolecules for research purposes, such as labeling proteins or creating targeted drug conjugates.
• Agrochemical Research: Acts as an intermediate in the development of novel herbicides, fungicides, and plant growth regulators.

Basic Information

Product Name	Phthalylglycyl Chloride
CAS No.	6780-38-7
Molecular Formula	C10H6ClNO3
Molecular Weight	223.61 g/mol
Synonyms	2-[(1,3-Dioxoisoindolin-2-yl)acetyl] chloride; N-Phthaloylglycyl chloride; Phthalimidoglycyl chloride; 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl chloride; Glycine, N-phthaloyl-, chloride; Phthalylglycine chloride; N-(Carboxymethyl)phthalimide acid chloride
EINECS	229-867-4

Quality Control

Our Phthalylglycyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay by titration and impurity profile analysis by HPLC, to ensure it meets the high-purity standards required for synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and specific test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.