Description

Ethylmorphine Hydrochloride Dihydrate is a pharmaceutical-grade salt form of the semi-synthetic opioid alkaloid, ethylmorphine. This compound is valued for its consistent quality and stability, making it a critical intermediate and reference standard in controlled pharmaceutical development and analytical research. It is primarily required by manufacturers and research institutions engaged in the production of antitussive medications, analytical method development, and pharmacological studies.

Application

• Pharmaceutical Intermediate: A key starting material or intermediate in the synthesis of specialized cough suppressants and other opioid-based therapeutics.
• Analytical Reference Standard: Used for quality control, method validation, and calibration in HPLC, GC, and spectrophotometric analyses within pharmaceutical laboratories.
• Pharmacological Research: Employed in preclinical studies to investigate opioid receptor activity, metabolic pathways, and comparative efficacy.
• Controlled Substance Manufacturing: Serves as a regulated active pharmaceutical ingredient (API) in the formulation of scheduled medicinal products under strict GMP compliance.
• Forensic Analysis: Utilized as a certified reference material for the identification and quantification of opioids in forensic toxicology.

Basic Information

Product Name	Ethylmorphine Hydrochloride Dihydrate
CAS No.	6746-59-4
Molecular Formula	C₁₉H₂₃NO₃·HCl·2H₂O
Molecular Weight	385.89 g/mol (monohydrate); 403.91 g/mol (dihydrate)
Synonyms	Ethylmorphine HCl Dihydrate; 3-Ethylmorphine Hydrochloride Dihydrate; Dionin; Codethyline Hydrochloride Dihydrate; Aethylmorphinhydrochlorid Dihydrat (German); Ethylmorphine Chlorhydrate Dihydrate (French); 7,8-Didehydro-4,5α-epoxy-3-ethoxy-17-methylmorphinan-6α-ol Hydrochloride Dihydrate
EINECS	229-838-0 (for the anhydrous form)

Quality Control

Our Ethylmorphine Hydrochloride Dihydrate is manufactured and tested under a strict quality management system. Each batch is analyzed to meet high-purity standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) is provided, detailing results for identity, assay, purity, and specified impurities. We support compliance with relevant pharmacopoeial guidelines (where applicable) and cGMP principles for API manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	8.0% - 10.0%
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 1.5%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.