Description

1-(4-Thio-β-D-Ribofuranosyl)Uracil is a modified nucleoside where the oxygen atom at the 4-position of the ribose sugar is replaced by sulfur, creating a thioribose derivative. This structural modification is of significant interest in medicinal chemistry and biochemistry for its potential to alter the biological activity and metabolic stability of nucleoside analogs. It serves as a key synthetic intermediate or building block for researchers and manufacturers developing novel antiviral agents, anticancer compounds, and other therapeutic nucleosides. The compound is primarily utilized in pharmaceutical R&D, biotechnology, and advanced organic synthesis laboratories.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used in studies investigating enzyme mechanisms, particularly those involving nucleoside metabolism and RNA/DNA synthesis inhibition.
• Proteomics & Genomics: Potential application in the development of probes or tools for studying nucleic acid structure and function.
• Medicinal Chemistry: Serves as a precursor for creating libraries of modified nucleosides for drug discovery and lead optimization programs.
• Antiviral Agent Development: Explored for the design of compounds targeting viral polymerases and reverse transcriptases.

Basic Information

Product Name	1-(4-Thio-β-D-Ribofuranosyl)Uracil
CAS No.	6741-73-7
Molecular Formula	C9H12N2O5S
Molecular Weight	260.27 g/mol
Synonyms	4'-Thiouridine; 4-Thiouridine; 1-(4-Thio-β-D-ribofuranosyl)uracil; β-D-4-Thiouridine; Uridine, 4-thio-; 4-Thio-β-D-ribofuranosyluracil; 4-S-Uridine
EINECS	Contact for details

Quality Control

Our 1-(4-Thio-β-D-Ribofuranosyl)Uracil is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment ensures the material meets the high standards required for pharmaceutical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.