Description

1-(4'-Thio-β-Ribofuranosyl)Thymine is a modified nucleoside analog where the oxygen atom in the ribose sugar ring is replaced by a sulfur atom. This structural modification is of significant interest in medicinal chemistry and biochemistry for the development of novel antiviral and anticancer agents. It serves as a critical building block and research chemical for pharmaceutical R&D, particularly in the synthesis of nucleoside-based prodrugs and the study of enzyme inhibition. Key industries that require this high-purity intermediate include pharmaceutical development, biotechnology research, and academic laboratories focused on nucleic acid chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving thymidine kinase and other nucleoside-metabolizing enzymes.
• Pro-drug Development: Employed in the design and synthesis of nucleoside pro-drugs to enhance bioavailability and targeting.
• Antiviral Agent Research: Investigated for its potential activity against viruses such as herpes simplex virus (HSV) and human immunodeficiency virus (HIV).
• Molecular Biology Tools: Can be incorporated into oligonucleotides to study structure-activity relationships and RNA/DNA interactions.
• Chemical Biology Probes: Utilized to create probes for studying cellular uptake and metabolism of modified nucleosides.

Basic Information

Product Name	1-(4'-Thio-β-Ribofuranosyl)Thymine
CAS No.	6741-71-5
Molecular Formula	C10H14N2O5S
Molecular Weight	274.29 g/mol
Synonyms	4'-Thiothymidine; 1-[(2R,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)thiolan-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione; 2'-Deoxy-4'-thio-5-methyluridine; 4'-Thio-dT; 4'-Thio-2'-deoxythymidine; 1-(4-Thio-β-D-ribofuranosyl)thymine; NSC 172924
EINECS	Contact for details

Quality Control

Our 1-(4'-Thio-β-Ribofuranosyl)Thymine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the high standards required for pharmaceutical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.