Description

Dextromethorphan Hydrobromide Monohydrate CAS NO 6700-34-1 is the hydrobromide salt monohydrate form of dextromethorphan, a well-established pharmaceutical active ingredient. This compound is a critical intermediate and final active pharmaceutical ingredient (API) for the formulation of safe and effective antitussive (cough suppressant) medications. It is primarily required by pharmaceutical manufacturers, research institutions, and fine chemical suppliers serving the global healthcare sector. Our supply is characterized by stringent quality control to ensure batch-to-batch consistency and regulatory compliance.

Application

• Pharmaceutical API: Primary use as the active ingredient in over-the-counter (OTC) and prescription cough syrups, lozenges, and capsules.
• Formulation Development: Used in R&D for developing new drug delivery systems, such as sustained-release or combination cold/flu remedies.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for HPLC, titration, and spectroscopic assays.
• Clinical Research: Employed in pharmacological studies investigating its antitussive and potential neuromodulatory effects.
• Generic Drug Manufacturing: A key raw material for producers of generic dextromethorphan-based pharmaceutical products.
• Veterinary Pharmaceuticals: Formulated into cough suppressants for animal health applications.

Basic Information

Product Name	Dextromethorphan Hydrobromide Monohydrate
CAS No.	6700-34-1
Molecular Formula	C18H25NO • HBr • H2O
Molecular Weight	370.31 g/mol
Synonyms	Dextromethorphan HBr Monohydrate; (+)-3-Methoxy-17-methyl-9α,13α,14α-morphinan Hydrobromide Monohydrate; DXM HBr Monohydrate; Romilar Hydrobromide Monohydrate; 1,2,3,9,10,10a-Hexahydro-6-methoxy-11-methyl-4H-10,4a-iminoethanophenanthrene Hydrobromide Monohydrate; (9α,13α,14α)-3-Methoxy-17-methylmorphinan Hydrobromide Monohydrate; NSC-83688 Monohydrate
EINECS	229-756-7

Quality Control

Our Dextromethorphan Hydrobromide Monohydrate is manufactured and tested under a GMP-compliant quality management system. Each batch undergoes comprehensive analytical testing to meet stringent specifications for identity, purity, and impurities. We provide full traceability and support regulatory filings. A detailed Certificate of Analysis (COA) confirming compliance with in-house pharmacopeial standards (aligned with USP/EP monographs) is available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.5% - 101.5% (on anhydrous basis)
Water Content (KF)	4.0% - 5.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%
Optical Rotation	+27.0° to +30.0° (c = 2 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.