Description

Cinobufaginol CAS NO 6691-83-4 is a bioactive bufadienolide compound, a key secondary metabolite derived from toad venom (Chansu). This high-purity reference standard is critical for pharmaceutical research and development, particularly in the study of natural product-based therapeutics. It is primarily utilized by research institutions, pharmaceutical companies, and analytical laboratories focused on oncology, cardiology, and traditional medicine modernization.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quality control and standardization of herbal extracts and finished pharmaceutical products.
• Bioactivity and Mechanism Studies: Used in in vitro and in vivo research to investigate its reported anti-tumor, cardiotonic, and analgesic properties.
• Analytical Method Development: Essential for developing and validating HPLC, LC-MS, and other chromatographic methods for the quantification of bufadienolides.
• Natural Product Chemistry: A key intermediate or target molecule for the synthesis, semi-synthesis, and structural modification of novel drug candidates.
• Preclinical Drug Development: Employed in pharmacokinetics (PK), pharmacodynamics (PD), and toxicology studies during early-stage drug discovery pipelines.

Basic Information

Product Name	Cinobufaginol
CAS No.	6691-83-4
Molecular Formula	C26H34O6
Molecular Weight	442.55 g/mol
Synonyms	Cinobufaginol; 3β,5β,14β-Trihydroxy-19-oxobufa-20,22-dienolide; 3-Epicinobufagin; Arenobufagin 3-epimer; Bufalin 3-epimer derivative; Venenum Bufonis metabolite; (3β,5β)-3,14,19-Trihydroxybufa-20,22-dienolide
EINECS	Contact for details

Quality Control

Our Cinobufaginol is manufactured and handled under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, IR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports applications requiring high data integrity and reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Handle the product carefully to avoid contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.