Description

3'-o-Acetyl-2'-Deoxyadenosine is a chemically modified nucleoside derivative, specifically an acetylated analog of deoxyadenosine. This compound is a crucial building block (phosphoramidite) in the solid-phase synthesis of oligonucleotides, enabling the introduction of specific functionalities or protective groups. It is primarily utilized by research institutions, pharmaceutical developers, and biotechnology companies engaged in nucleic acid research, antisense therapy development, and the production of diagnostic probes.

Application

• Oligonucleotide Synthesis: Serves as a key protected intermediate in the automated synthesis of DNA and RNA strands for research and therapeutic applications.
• Antisense & siRNA Development: Used in the preparation of modified oligonucleotides for gene silencing and therapeutic agent discovery.
• Diagnostic Probe Manufacturing: A vital raw material for creating labeled probes used in PCR, sequencing, and microarray technologies.
• Pharmaceutical Research: Employed as a precursor in the development of nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Used in studies investigating enzyme mechanisms, nucleic acid structure, and metabolic pathways involving nucleosides.

Basic Information

Product Name	3'-o-Acetyl-2'-Deoxyadenosine
CAS No.	6612-73-3
Molecular Formula	C12H15N5O4
Molecular Weight	293.28 g/mol
Synonyms	2'-Deoxy-3'-O-acetyladenosine; 3'-O-Acetyl-2'-deoxyadenosine; 9-[(2R,3R,5R)-3-(Acetyloxy)-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-6-amine; 3'-Acetyl-2'-deoxyadenosine; 3'-O-Acetyldeoxyadenosine; N6-Amino-3'-O-acetyl-2'-deoxyadenosine; dA(Ac)
EINECS	Contact for details

Quality Control

Our 3'-o-Acetyl-2'-Deoxyadenosine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry to ensure identity and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.