Description

3'-o-Acetyladenosine is a chemically modified nucleoside derivative, specifically an acetylated form of adenosine. This modification is crucial for protecting specific hydroxyl groups during oligonucleotide synthesis, enabling the precise construction of RNA and DNA sequences. It serves as a vital building block and synthetic intermediate for researchers and manufacturers in pharmaceutical development, molecular biology, and diagnostic reagent production.

Application

• Pharmaceutical Intermediate: Key starting material or protected monomer in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Serves as a protected phosphoramidite precursor for solid-phase synthesis of RNA and modified DNA strands.
• Biochemical Research: Used in enzymatic studies and as a substrate analog to investigate adenosine-related metabolic pathways and kinase activity.
• Prodrug Development: The acetyl group can be utilized in prodrug strategies to enhance the bioavailability or targeting of adenosine-based therapeutics.
• Diagnostic Reagent Manufacturing: Employed in the production of labeled probes and reagents for genetic testing and molecular diagnostics.

Basic Information

Product Name	3'-o-Acetyladenosine
CAS No.	6554-21-8
Molecular Formula	C12H15N5O5
Molecular Weight	309.28 g/mol
Synonyms	Adenosine, 3'-acetate; 3'-O-Acetyladenosine; 3'-Acetyladenosine; N6-Adenosine 3'-acetate; 9-β-D-Ribofuranosyladenine 3'-acetate; 3'-Acetoxyadenosine; 3'-O-Ac-Ado
EINECS	229-481-4

Quality Control

Our 3'-o-Acetyladenosine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.