Description

5'-o-Trityluridine is a key nucleoside derivative where the 5'-hydroxyl group is protected by a trityl moiety. This compound is of significant importance in organic synthesis, particularly in the production of modified oligonucleotides and nucleotide analogs. It serves as a crucial building block for researchers and manufacturers in the pharmaceutical and biotechnology industries, enabling the development of novel therapeutics and diagnostic tools.

Application

• Oligonucleotide Synthesis: A vital intermediate in solid-phase and solution-phase synthesis of DNA and RNA sequences, where the trityl group acts as a protecting group.
• Antiviral Drug Development: Used in the research and production of nucleoside-based antiviral agents targeting various viruses.
• Pharmaceutical Intermediates: Serves as a precursor in the synthesis of more complex active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in studies involving nucleic acid chemistry, enzyme mechanisms, and metabolic pathways.
• Labeled Compound Production: Acts as a starting material for the synthesis of isotopically or fluorescently labeled nucleotides for diagnostic assays.
• Prodrug Synthesis: Utilized in creating prodrug forms of nucleoside analogs to improve bioavailability and targeting.

Basic Information

Product Name	5'-o-Trityluridine
CAS No.	6554-10-5
Molecular Formula	C28H26N2O6
Molecular Weight	486.52 g/mol
Synonyms	5'-O-(Triphenylmethyl)uridine; Uridine, 5'-O-trityl-; 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-[[tris(phenyl)methyl]oxy]oxolan-2-yl]pyrimidine-2,4-dione; 5'-O-Trityl-uridine; Trityluridine; 5'-O-TRT-Uridine; N-Trityluridine; 5'-O-(Triphenylmethyl)-2'-deoxyuridine (common misnomer, verify structure)
EINECS	Contact for details

Quality Control

Our 5'-o-Trityluridine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.