Description

2-Chloro-4-Methyl-1,3,2-Dioxaphospholane is a specialized organophosphorus compound that serves as a versatile and reactive intermediate in advanced chemical synthesis. Its value lies in its ability to act as a key building block for introducing phosphoryl and cyclic phosphate ester functionalities into target molecules. This chemical is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and materials science sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of nucleotide analogs, prodrugs, and other bioactive molecules containing cyclic phosphate esters.
• Polymer Chemistry: Used as a monomer or modifying agent for creating flame-retardant polymers, specialty polyphosphoesters, and functional materials with tailored properties.
• Agrochemical Synthesis: Employed in the development of novel insecticides, herbicides, and plant growth regulators that utilize phosphonate or phosphate ester chemistry.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing chiral or multidentate phosphorus-containing ligands used in asymmetric catalysis.
• Surface Modification Agent: Can be used to functionalize surfaces (e.g., silica, metals) with phosphate-based layers for improved adhesion, corrosion resistance, or biocompatibility.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new reactions in organophosphorus chemistry and developing novel synthetic methodologies.

Basic Information

Product Name	2-Chloro-4-Methyl-1,3,2-Dioxaphospholane
CAS No.	6362-86-3
Molecular Formula	C₃H₆ClO₂P
Molecular Weight	140.50 g/mol
Synonyms	2-Chloro-4-methyl-1,3,2-dioxaphospholane; 4-Methyl-2-chloro-1,3,2-dioxaphospholane; 2-Chloro-4-methyl-1,3,2-dioxaphospholane 2-oxide (common misnomer); Methyl ethylene chlorophosphite (cyclic); 2-Chloro-4-methyl-1,3,2-dioxaphospholane-2-oxide; Cyclic methyl ethylene chlorophosphite; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-Methyl-1,3,2-Dioxaphospholane is produced and tested under strict quality management protocols to ensure consistency and reliability for your synthetic processes. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by GC or NMR), identity confirmation, and impurity profiles. Our quality system is designed to support cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.