Description

2'-Deoxyguanosine 3'-(Dihydrogen Phosphate) is a crucial nucleotide monophosphate derivative, serving as a fundamental building block in molecular biology and pharmaceutical research. Its primary value lies in its role as a key intermediate for the synthesis of oligonucleotides, DNA probes, and therapeutic nucleic acids. This high-purity biochemical is essential for researchers and manufacturers in the biotechnology, pharmaceutical, and diagnostic sectors who require reliable, high-quality raw materials for advanced applications.

Application

• Oligonucleotide Synthesis: A critical phosphoramidite precursor for solid-phase synthesis of DNA and RNA sequences.
• Pharmaceutical Intermediates: Used in the research and development of nucleotide-based antiviral and anticancer drugs.
• Biochemical Research: Serves as a substrate for enzymes like kinases and polymerases in enzymatic studies and assay development.
• Diagnostic Reagent Manufacturing: A key component in the production of labeled probes for PCR, sequencing, and microarray technologies.
• Reference Standard: Used as an analytical standard in quality control laboratories for HPLC and mass spectrometry.
• Cell Culture & Microbiology: Employed in specialized media formulations for nucleotide-requiring microorganisms and cell lines.

Basic Information

Product Name	2'-Deoxyguanosine 3'-(Dihydrogen Phosphate)
CAS No.	6220-62-8
Molecular Formula	C10H14N5O7P
Molecular Weight	347.22 g/mol
Synonyms	2'-Deoxyguanosine 3'-Monophosphate; dGMP; Deoxyguanylic Acid; 2'-Deoxyguanosine 3'-Phosphate; 2'-Deoxyguanosine 3'-(Dihydrogen Phosphate); 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-amino-3H-purin-2-one 3'-(dihydrogen phosphate); Guanosine, 2'-deoxy-, 3'-(dihydrogen phosphate); dGuo-3'-P
EINECS	228-300-5

Quality Control

Our 2'-Deoxyguanosine 3'-(Dihydrogen Phosphate) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and stringent tests for residual solvents and endotoxins where applicable. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or desiccant after each use to prevent degradation. For short-term use, storage at 2-8°C is acceptable.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
pH (1% Solution)	2.5 - 4.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.