Description

3',5'-Di-o-Acetyl-5-Bromo-2'-Deoxy-D-Uridine is a key nucleoside derivative and a vital intermediate in synthetic organic chemistry. This compound matters for its role as a versatile building block in the development of antiviral and anticancer agents, particularly in the synthesis of modified nucleosides and oligonucleotides. Pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers need this high-purity intermediate to support their drug discovery and development pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used in the preparation of modified DNA/RNA strands for research and therapeutic applications.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism.
• Prodrug Development: The acetyl-protected groups make it a candidate for prodrug strategies to enhance bioavailability.
• Labeled Compound Synthesis: Acts as a starting material for the preparation of bromine-labeled or radio-labeled nucleosides for tracing studies.
• Academic & Industrial R&D: Essential for chemical libraries and exploratory synthesis in medicinal chemistry programs.

Basic Information

Product Name	3',5'-Di-o-Acetyl-5-Bromo-2'-Deoxy-D-Uridine
CAS No.	6161-23-5
Molecular Formula	C13H15BrN2O7
Molecular Weight	391.17 g/mol
Synonyms	5-Bromo-2'-deoxyuridine 3',5'-diacetate; 5-BrdU 3',5'-diacetate; 3',5'-Diacetyl-5-bromo-2'-deoxyuridine; 5-Bromo-1-[(2R,4S,5R)-4-acetoxy-5-(acetoxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione; 5-Bromo-2'-deoxyuridine diacetate; 5-BrdUrd diacetate; NSC 38297
EINECS	Contact for details

Quality Control

Our 3',5'-Di-o-Acetyl-5-Bromo-2'-Deoxy-D-Uridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants and inert atmosphere packing.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.