Description

Triphenylacetyl Chloride is a specialized organic reagent characterized by its bulky triphenylmethyl group attached to an acid chloride functionality. This compound matters as a highly effective acylating and protecting group agent, offering unique steric hindrance that can direct regioselectivity in complex synthetic pathways. It is primarily needed by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for synthesizing novel compounds, including active pharmaceutical ingredients (APIs) and specialty polymers.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for introducing the trityl (triphenylmethyl) group, used in the production of specialized APIs and fine chemicals.
• Peptide Chemistry: Serves as a protecting group for amino acids during solid-phase peptide synthesis (SPPS), particularly for side-chain protection.
• Polymer Science: Used as a modifying agent or initiator in the synthesis of specialty polymers with tailored properties.
• Organic Synthesis Reagent: Employed as a robust acylating agent for alcohols and amines in research-scale and pilot-scale reactions.
• Material Science Research: Facilitates the surface functionalization of materials and the creation of molecular scaffolds for advanced applications.
• Catalyst and Ligand Preparation: Intermediate in the synthesis of complex organometallic catalysts and ligands.

Basic Information

Product Name	Triphenylacetyl Chloride
CAS No.	6068-70-8
Molecular Formula	C20H15ClO
Molecular Weight	306.78 g/mol
Synonyms	Trityl Chloride; Triphenylmethyl Chloride (common misnomer, related); α,α,α-Triphenylacetyl Chloride; 2,2,2-Triphenylacetyl Chloride; (Triphenylacetyl) Chloride; Chlorotriphenylacetate; Triphenylacetic Acid Chloride; TPA-Cl
EINECS	228-001-5

Quality Control

Our Triphenylacetyl Chloride is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after initial opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	142 - 147 °C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.