Description

Thymidine-5'-Aldehyde is a high-purity, chemically modified nucleoside derivative, serving as a critical building block and intermediate in advanced organic synthesis. Its unique aldehyde functionality at the 5' position makes it a versatile reagent for cross-coupling reactions, bioconjugation, and the synthesis of complex nucleotide analogs. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors, particularly in the development of antiviral agents, prodrugs, and labeled probes for diagnostic applications.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Bioconjugation Chemistry: Used for site-specific labeling of biomolecules (proteins, oligonucleotides) via its reactive aldehyde group.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed reactions for creating carbon-carbon bonds in complex molecules.
• Prodrug Development: Utilized in designing masked nucleotide prodrugs to enhance bioavailability and targeting.
• Chemical Biology Research: A valuable tool for studying enzyme mechanisms and nucleic acid metabolism.
• Material Science: Potential monomer for creating functionalized polymers and hydrogels with specific biological activities.

Basic Information

Product Name	Thymidine-5'-Aldehyde
CAS No.	6049-39-4
Molecular Formula	C10H12N2O5
Molecular Weight	240.21 g/mol
Synonyms	5'-Aldehydethymidine; 5'-Deoxy-5'-oxothymidine; Thymidine 5'-carboxaldehyde; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; 2'-Deoxythymidine-5'-aldehyde; 5'-Formyl-2'-deoxythymidine; Thymidin-5'-al
EINECS	Contact for details

Quality Control

Our Thymidine-5'-Aldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.