Description

3'-o-Methyluridine is a modified nucleoside derivative of uridine, where a methyl group is attached to the 3' oxygen of the ribose sugar. This specific molecular modification makes it a valuable building block and research chemical in advanced biochemical synthesis. It is primarily utilized in the development of oligonucleotides, prodrugs, and as a reference standard in analytical chemistry. This compound is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on nucleic acid chemistry and drug discovery.

Application

• Oligonucleotide Synthesis: A key monomer for the solid-phase synthesis of modified RNA and DNA strands for therapeutic and diagnostic applications.
• Pharmaceutical Research: Used as an intermediate in the development of nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Tool: Serves as a substrate or inhibitor in enzymatic studies to understand polymerase and nuclease activity.
• Analytical Reference Standard: Employed in HPLC, LC-MS, and NMR for the identification, quantification, and purity assessment of related nucleosides.
• Antisense Technology: Incorporated into antisense oligonucleotides to modulate stability, binding affinity, and pharmacokinetic properties.
• Academic Research: Fundamental studies in nucleic acid structure, function, and metabolism within university and institutional laboratories.

Basic Information

Product Name	3'-o-Methyluridine
CAS No.	6038-59-1
Molecular Formula	C10H14N2O6
Molecular Weight	258.23 g/mol
Synonyms	3'-O-Methyluridine; 3'-Methoxyuridine; Uridine, 3'-O-methyl-; 1-[(2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; 3'-O-Methyl-uridine; 2',3'-O-Dimethyluridine (related isomer); 3'-Methyluridine; 3'-OMe-Urd
EINECS	Contact for details

Quality Control

Our 3'-o-Methyluridine is produced under a quality management system to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC for assay and related substances, NMR for structural confirmation, and tests for residual solvents and moisture content. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support research and cGMP-grade requirements, with documentation available for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.