Description

Methyldopate is the methyl ester derivative of the antihypertensive agent methyldopa. This compound serves as a key pharmaceutical intermediate and reference standard in the research and development of cardiovascular medications. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the synthesis of active pharmaceutical ingredients (APIs) and analytical method development. Its defined chemical structure makes it valuable for quality control and regulatory compliance within the pharmaceutical supply chain.

Application

• Pharmaceutical Intermediate: Critical building block in the synthetic pathway for producing methyldopa and related antihypertensive drugs.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for HPLC, GC, or LC-MS method development and validation.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the research-scale and process development for novel cardiovascular therapeutics.
• Biochemical Research: Utilized in pharmacological studies to investigate the metabolism and mechanism of action of catecholamine-based drugs.
• Quality Control & Assurance: Serves as an impurity standard or system suitability compound in the quality testing of methyldopa API and finished dosage forms.

Basic Information

Product Name	Methyldopate
CAS No.	6014-30-8
Molecular Formula	C11H15NO4
Molecular Weight	225.24 g/mol
Synonyms	L-α-Methyl-3,4-dihydroxyphenylalanine methyl ester; Methyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoate; Methyldopa methyl ester; L-Methyldopate; MK-351; Aldomet ester
EINECS	Contact for details

Quality Control

Our Methyldopate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support regulatory filings. Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents are available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.