Description

Ethyl Bromodifluoroacetate is a versatile fluorinated building block essential for introducing the difluoroacetate moiety into target molecules. Its high reactivity, particularly in nucleophilic substitution and coupling reactions, makes it a critical intermediate for advanced chemical synthesis. This compound is primarily sought after by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials sectors for developing novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides with enhanced activity and environmental profile.
• Material Science: Precursor for fluorinated monomers and polymers that impart unique properties like oil/water repellency and chemical resistance.
• Organic Synthesis Reagent: Employed in nucleophilic substitution reactions to introduce the -CF2CO2Et group, enabling the synthesis of complex fluorinated esters and acids.
• Ligand and Catalyst Development: Serves as a starting material for creating novel fluorinated ligands used in asymmetric catalysis.
• Fluorine Chemistry Research: A fundamental reagent in academic and industrial R&D for exploring new reactions and methodologies in organofluorine chemistry.

Basic Information

Product Name	Ethyl Bromodifluoroacetate
CAS No.	667-27-6
Molecular Formula	C4H5BrF2O2
Molecular Weight	202.98 g/mol
Synonyms	Bromodifluoroacetic Acid Ethyl Ester; Ethyl 2-Bromo-2,2-difluoroacetate; 2-Bromo-2,2-difluoroacetic Acid Ethyl Ester; Difluoro(bromo)acetic Acid Ethyl Ester; Ethyl α-Bromo-α,α-difluoroacetate; Bromodifluoroethyl Acetate; EINECS 211-560-2
EINECS	211-560-2

Quality Control

Our Ethyl Bromodifluoroacetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to guarantee it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Purity (GC Area %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.6 g/mL
Refractive Index (n20/D)	~1.39

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.