Description

2,2,3,3-Tetrafluoropropionyl Chloride is a highly reactive fluorinated acid chloride derivative, serving as a critical building block for introducing the tetrafluoropropionyl moiety into target molecules. Its primary value lies in enabling the synthesis of advanced materials and active pharmaceutical ingredients (APIs) with enhanced properties such as metabolic stability and lipophilicity. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty materials sectors seeking to develop novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: Key reagent for synthesizing fluorinated active pharmaceutical ingredients (APIs) and prodrugs, particularly in antiviral and anticancer research.
• Agrochemical Synthesis: Used in the production of advanced fluorinated pesticides and herbicides, where the fluorine atoms improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated components in electronic display materials, enhancing thermal stability and optical properties.
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, improving chemical resistance, surface properties, and durability.
• Organic Synthesis Reagent: A versatile acylating agent for amide and ester formation in complex organic synthesis, especially where fluorination is desired.
• Surface Treatment Agents: Used in the synthesis of fluorinated surfactants and coatings that provide oil, water, and stain resistance.

Basic Information

Product Name	2,2,3,3-Tetrafluoropropionyl Chloride
CAS No.	663-73-0
Molecular Formula	C3HF4ClO
Molecular Weight	164.49 g/mol
Synonyms	Perfluoropropionyl Chloride (common misnomer); 2,2,3,3-Tetrafluoropropanoic Acid Chloride; Tetrafluoropropanoyl Chloride; 3,3,4,4-Tetrafluorobutyryl Chloride (isomeric); Propionyl chloride, 2,2,3,3-tetrafluoro-; NSC 9235; EINECS 211-553-6
EINECS	211-553-6

Quality Control

Our 2,2,3,3-Tetrafluoropropionyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and titration methods, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at temperatures between 2°C and 8°C (refrigerated) to maximize stability. Due to its hygroscopic and moisture-sensitive nature, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Acidity (Titration)	≤ 1.0% (as HF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.