Description

Guanethidine Sulfate is a high-purity pharmaceutical active ingredient and research chemical. This compound is a potent antihypertensive agent that functions as a postganglionic adrenergic neuron blocker. It is primarily utilized in pharmaceutical research and development, as well as in the synthesis of reference standards for analytical and pharmacological studies. Key industries requiring this material include pharmaceutical manufacturing, contract research organizations (CROs), and academic research institutions.

Application

• Pharmaceutical Active Ingredient (API): Used in the research and development of antihypertensive medications.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method validation in pharmaceutical labs.
• Pharmacological Research: Employed in preclinical studies to investigate autonomic nervous system function and mechanisms of blood pressure regulation.
• Biochemical Research: Used as a tool compound to study norepinephrine release and reuptake in neuronal systems.
• Chemical Synthesis Intermediate: Acts as a key building block or precursor in the synthesis of more complex chemical entities for research purposes.

Basic Information

Product Name	Guanethidine Sulfate
CAS No.	645-43-2
Molecular Formula	C10H22N4 · H2SO4
Molecular Weight	296.38 g/mol (free base: 198.31 g/mol)
Synonyms	Guanethidine Monosulfate; 2-[2-(1,4,5,6-Tetrahydro-1-methylpyrimidin-2-yl)ethyl]guanidine sulfate; Ismelin Sulfate; Abapressin; Antipres; Iporal; Octadin; Sanotensin; Visutensil; Eutensol
EINECS	211-455-9

Quality Control

Our Guanethidine Sulfate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing results for assay, related substances, residual solvents, and other critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.