Description

Apocholic Acid CAS NO 641-81-6 is a secondary bile acid derivative, a key intermediate in the study of bile acid metabolism and signaling pathways. Its significance lies in its role as a research-grade biochemical for investigating liver function, cholesterol homeostasis, and intestinal receptor activity. This compound is essential for pharmaceutical R&D, academic research, and diagnostic reagent development, particularly for studies involving FXR (farnesoid X receptor) and TGR5 (G protein-coupled bile acid receptor) modulation.

Application

• Pharmaceutical Research & Development: Critical intermediate in the synthesis and study of novel therapeutics targeting metabolic and liver diseases.
• Biochemical Research: Used as a reference standard and tool compound for studying bile acid biosynthesis, transport, and receptor pharmacology.
• Diagnostic Reagent Manufacturing: Serves as a key component in the development of enzymatic assays and diagnostic kits for liver function and bile acid disorders.
• Academic & Life Science Studies: Employed in university and institutional labs for fundamental research on cholesterol metabolism and gastrointestinal biology.
• Metabolite Standard: Used in analytical chemistry (HPLC, LC-MS) as a calibration standard for the quantification of bile acids in biological samples.

Basic Information

Product Name	Apocholic Acid
CAS No.	641-81-6
Molecular Formula	C24H38O4
Molecular Weight	390.56 g/mol
Synonyms	3α,12α-Dihydroxy-5β-cholan-24-oic Acid; Allocholic Acid; 5β-Cholan-24-oic acid, 3α,12α-dihydroxy-; 3α,12α-Dihydroxycholanic Acid; NSC 4918; 5β-Apocholic Acid
EINECS	211-380-1

Quality Control

Our Apocholic Acid is produced under a strict quality management system to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.