Description

Pramoxine Hydrochloride is a topical anesthetic agent belonging to the ester class of local anesthetics. It is valued for its effective numbing properties and relatively low potential for causing allergic reactions compared to other agents like benzocaine. This compound is essential for formulators and manufacturers in the pharmaceutical and personal care industries seeking to develop products that provide temporary relief from pain and itching. Its primary utility lies in over-the-counter (OTC) topical preparations designed for dermatological and minor surgical applications.

Application

Pramoxine Hydrochloride is utilized in a variety of topical formulations due to its anesthetic and antipruritic effects. Key application areas include:

• Topical Analgesic Creams and Ointments: For temporary relief of pain associated with minor cuts, burns, scrapes, and insect bites.
• Anti-Itch and Pruritus Formulations: Used in products to alleviate itching caused by conditions like eczema, psoriasis, poison ivy, and hemorrhoids.
• Dermatological Preparations: Incorporated into medicated lotions, gels, and sprays for skin protection and comfort.
• Pre-Procedural Topical Anesthetics: Applied before minor dermatological procedures, needle sticks, or laser treatments to reduce discomfort.
• Veterinary Topical Products: Used in animal healthcare for similar analgesic and antipruritic purposes.
• Cosmetic and Personal Care Products: Sometimes included in formulations like after-shave lotions or products designed to soothe irritated skin.

Basic Information

Product Name	Pramoxine Hydrochloride
CAS No.	637-58-1
Molecular Formula	C17H27NO3 • HCl
Molecular Weight	329.86 g/mol (as hydrochloride salt)
Synonyms	Pramocaine Hydrochloride; 4-[3-(4-Butoxyphenoxy)propyl]morpholine Hydrochloride; Pramoxine HCl; Tronothane Hydrochloride; Proctofoam HC (active ingredient); Fleet Relief (active ingredient); Itch-X (active ingredient); Morpholine, 4-[3-(p-butoxyphenoxy)propyl]-, hydrochloride
EINECS	211-305-5

Quality Control

Our Pramoxine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing parameters such as assay, related substances, residual solvents, and identification. We can supply material compliant with relevant pharmacopeial monographs (e.g., USP-NF) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.