Description

2-Ethoxyethyl Chloroformate is a versatile chloroformate ester widely used as a key reagent in organic synthesis, particularly for the introduction of the 2-ethoxyethoxycarbonyl protecting group. This compound matters for its role in facilitating complex chemical transformations, offering a balance of reactivity and selectivity for advanced intermediate manufacturing. It is primarily needed by pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active ingredients, polymers, and fine chemicals where controlled functionalization is critical.

Application

• Pharmaceutical intermediate synthesis, particularly for peptide and carbamate prodrug development.
• Agrochemical manufacturing as a building block for herbicides and insecticides.
• Polymer chemistry as a monomer or modifying agent for specialty resins and coatings.
• Organic synthesis reagent for introducing the 2-ethoxyethoxycarbonyl (Eoc) protecting group for amines and alcohols.
• Production of surfactants and emulsifiers with specific hydrophilic-lipophilic balance properties.
• Research and development of novel chemical entities in academic and industrial laboratories.
• Fine chemical production for flavors, fragrances, and advanced material precursors.

Basic Information

Product Name	2-Ethoxyethyl Chloroformate
CAS No.	628-64-8
Molecular Formula	C5H9ClO3
Molecular Weight	152.57 g/mol
Synonyms	Ethyleneglycol monoethyl ether chloroformate; 2-Ethoxyethyl carbonochloridate; 2-Ethoxyethoxycarbonyl chloride; Ethoxyethyl chloroformate; Eoc-Cl; 1-Chloroformyloxy-2-ethoxyethane; 2-(Ethoxy)ethyl chloroformate; β-Ethoxyethyl chloroformate
EINECS	211-051-8

Quality Control

Our 2-Ethoxyethyl Chloroformate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing including GC, HPLC, and NMR to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request, supporting compliance with cGMP and ISO 9001 standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at temperatures between 2°C and 8°C (refrigerated) or as specified on the label. Due to its hygroscopic (moisture-sensitive) nature and reactivity with strong acids/organic solvents, keep the container tightly sealed under an inert atmosphere such as nitrogen or argon. Isolate from incompatible materials including strong bases, amines, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Acidity (Titration)	≤ 0.5%
Density at 20°C	1.15 - 1.20 g/mL
Refractive Index (n20D)	1.415 - 1.425

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.