Description

3-Chloropropyl Chloroformate is a versatile bifunctional reagent featuring both a chloroformate and a chloropropyl group, making it a valuable building block in organic synthesis. This compound is essential for introducing protected amine or alcohol functionalities and for constructing specialized molecular scaffolds. It is particularly critical for manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), especially for constructing prodrugs and molecules with amine-protecting groups.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where its bifunctional nature allows for the creation of complex heterocycles.
• Polymer Chemistry: Serves as a monomer or cross-linking agent for modifying polymer chains and creating functionalized resins with specific properties.
• Peptide & Protein Modification: Employed to introduce specific tags or protective groups onto amino acids during solid-phase peptide synthesis.
• Ligand & Catalyst Development: Useful for synthesizing specialized ligands for metal complexes and organocatalysts used in asymmetric synthesis.
• Surface Functionalization: Applied to modify material surfaces (e.g., silica, polymers) to introduce reactive chloroformate groups for further conjugation.

Basic Information

Product Name	3-Chloropropyl Chloroformate
CAS No.	628-11-5
Molecular Formula	C4H6Cl2O2
Molecular Weight	157.00 g/mol
Synonyms	3-Chloropropyl carbonochloridate; Chloroformic acid 3-chloropropyl ester; 3-Chloro-1-propyl chloroformate; γ-Chloropropyl chloroformate; 1-Chloro-3-(chlorocarbonyloxy)propane; 3-Chloropropanol chloroformate; Propane, 1-chloro-3-(chloroformyloxy)-
EINECS	211-034-0

Quality Control

Our 3-Chloropropyl Chloroformate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C. Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	1.30 - 1.35 g/mL
Refractive Index (n20D)	1.445 - 1.455

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.