Description

Holocaine Hydrochloride is a pharmaceutical-grade local anesthetic compound, also known as Phenacaine Hydrochloride. It is a critical active pharmaceutical ingredient (API) valued for its rapid onset of action and efficacy in topical ophthalmic and mucous membrane anesthesia. This high-purity compound is essential for manufacturers in the pharmaceutical and life sciences sectors developing specialized anesthetic formulations, diagnostic solutions, and research applications.

Application

• Ophthalmic Anesthetic Formulations: Primary use in eye drops and solutions for procedures like tonometry, foreign body removal, and minor ocular surgery.
• Topical Anesthetic Preparations: Used in creams, gels, or sprays for anesthesia of the ear, nose, throat, and other accessible mucous membranes.
• Veterinary Medicine: Employed in topical anesthetic products for veterinary diagnostic and minor surgical procedures.
• Pharmaceutical Research & Development: Serves as a reference standard and key intermediate in the R&D of new local anesthetic agents.
• Diagnostic Agent Production: Incorporated into specialized diagnostic solutions where temporary local numbness is required.

Basic Information

Product Name	Holocaine Hydrochloride
CAS No.	620-99-5
Molecular Formula	C₁₈H₂₂N₂O₂·HCl
Molecular Weight	352.84 g/mol
Synonyms	Phenacaine Hydrochloride; Holocaine HCl; 2-(Diethoxyamino)ethyl 4-Aminobenzoate Hydrochloride; 4-Aminobenzoic Acid 2-(Diethylamino)ethyl Ester Hydrochloride; Diethylaminoethyl p-Aminobenzoate Hydrochloride; EINECS 210-673-8
EINECS	210-673-8

Quality Control

Our Holocaine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with pharmaceutical standards. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in its original packaging to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.