Description

Dl-α-Methyltyrosine CAS NO 620-30-4 is a synthetic amino acid derivative that acts as a competitive inhibitor of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis. This mechanism of action makes it a critical biochemical tool and pharmaceutical intermediate for research and development targeting the adrenergic system. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research laboratories engaged in neuroscience, endocrinology, and cardiovascular drug discovery.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of active pharmaceutical ingredients (APIs) targeting hypertension and pheochromocytoma.
• Biochemical Research: Used as a standard or reagent in enzymatic assays to study tyrosine hydroxylase activity and catecholamine (dopamine, norepinephrine, epinephrine) synthesis pathways.
• Neuroscience Studies: Employed in vitro and in vivo to induce controlled catecholamine depletion, facilitating research on sympathetic nervous system function, behavior, and stress responses.
• Reference Standard: Serves as a high-purity certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Metabolite Analysis: Used in metabolic studies to trace and quantify the downstream effects of tyrosine hydroxylase inhibition.

Basic Information

Product Name	Dl-α-Methyltyrosine
CAS No.	620-30-4
Molecular Formula	C10H13NO3
Molecular Weight	195.22 g/mol
Synonyms	α-Methyl-L-tyrosine; AMT; DL-α-Methyltyrosine; (±)-α-Methyl-4-hydroxybenzenealanine; Metirosine; L-α-Methyltyrosine; (2S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid (for L-isomer); Metyrosine
EINECS	210-637-5

Quality Control

Our Dl-α-Methyltyrosine is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific pharmacopeial standards (e.g., USP, EP) or internal specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Optical Rotation	Specific range available per grade

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.