Description

Thymidine 5-(Tetrahydrogen Triphosphate), 3-Deoxy- is a chemically modified nucleotide triphosphate analog, also known as 3'-Deoxy-5'-TTP, which plays a critical role in biochemical research and molecular biology applications. Its primary value lies in its ability to act as a chain terminator in enzymatic DNA synthesis, making it an essential tool for sequencing and nucleic acid analysis. This high-purity biochemical is indispensable for pharmaceutical R&D, academic research institutions, and diagnostic kit manufacturers focused on virology and genetic studies.

Application

• Molecular Biology Research: Used as a substrate analog in DNA polymerase assays and enzymatic DNA synthesis studies.
• Virology & Antiviral Drug Development: Serves as a key intermediate or reference standard in the research of nucleoside reverse transcriptase inhibitors (NRTIs).
• DNA Sequencing: Employed in Sanger sequencing and other analytical techniques as a controlled chain-terminating nucleotide.
• Biochemical Assay Standard: Acts as a high-purity calibrant or reference material in quantitative PCR (qPCR) and other nucleic acid amplification quality control protocols.
• Enzymology Studies: Utilized to investigate the kinetics and specificity of polymerases and other nucleic acid-metabolizing enzymes.
• Diagnostic Reagent Manufacturing: Incorporated as a specialized raw material in the production of kits for genetic testing and pathogen detection.

Basic Information

Product Name	Thymidine 5-(Tetrahydrogen Triphosphate), 3-Deoxy-
CAS No.	611-60-9
Molecular Formula	C10H17N2O13P3
Molecular Weight	482.16 g/mol
Synonyms	3'-Deoxy-5'-TTP; 3'-Deoxythymidine 5'-triphosphate; 2'-Deoxythymidine 5'-triphosphate, 3'-deoxy-; Cordycepin 5'-triphosphate analog; dTTP, 3'-deoxy-; 3'-Deoxy-thymidine-triphosphate; Thymidine 3'-deoxy-5'-triphosphate
EINECS	Contact for details

Quality Control

Every batch of our 3'-Deoxy-5'-TTP is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of purity and consistency, suitable for sensitive research applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (HPLC), identity (NMR/IR), and impurity profiles. Our quality system is designed to meet the stringent requirements of GMP and ISO guidelines for fine biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Allow the sealed container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
pH (1% Solution)	6.0 - 8.0
Endotoxin (LAL)	< 10 EU/mg
Biological Activity	Conforms in polymerase assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.