Description

2-Iodobenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to introduce the 2-iodobenzoyl moiety, a key structural feature for constructing complex molecules with tailored electronic and steric properties. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries, where it is used to create active ingredients, ligands, and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated aromatic scaffolds for bioactivity or as a handle for further functionalization via cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the iodine atom can be pivotal for metabolic stability and target binding.
• Ligand and Catalyst Preparation: Employed in the creation of specialized ligands for transition metal catalysis, such as palladium-catalyzed cross-couplings (Suzuki, Sonogashira), where the iodine serves as an excellent leaving group.
• Material Science Research: Acts as a monomer or functionalization agent in the synthesis of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological processes, leveraging the reactivity of the acid chloride and the versatility of the iodine handle.
• Custom Synthesis and Contract Manufacturing: A valuable reagent for fine chemical and custom synthesis houses serving the global R&D and scale-up markets.

Basic Information

Product Name	2-Iodobenzoyl Chloride
CAS No.	609-67-6
Molecular Formula	C7H4ClIO
Molecular Weight	266.46 g/mol
Synonyms	o-Iodobenzoyl Chloride; 2-Iodobenzoic Acid Chloride; Benzoic acid, 2-iodo-, chloride; 2-Iodobenzenecarbonyl chloride; o-Iodobenzoic acid chloride; 2-Carboxyiodobenzene chloride; Iodobenzoyl chloride (o-)
EINECS	210-200-8

Quality Control

Every batch of 2-Iodobenzoyl Chloride is manufactured and tested under a strict quality management system to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by HPLC/NMR), identity (IR), and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring the material meets the stringent requirements of pharmaceutical and advanced R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and moisture-sensitive nature, the container must be kept under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	White to pale yellow crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.