Description

11α,21-Dihydroxypregn-4-Ene-3,20-Dione is a high-purity steroid derivative of significant importance in pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of various corticosteroid drugs, which are essential for treating inflammatory and autoimmune conditions. It is primarily required by pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers focused on producing active pharmaceutical ingredients (APIs) and reference standards.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent corticosteroid APIs such as hydrocortisone and its derivatives.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development, validation, and impurity profiling of steroid-based pharmaceuticals.
• Biochemical Research: Employed in metabolic pathway studies and as a precursor in investigating steroid hormone biosynthesis and regulation.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for producing specialized steroid analogs for clinical research.

Basic Information

Product Name	11α,21-Dihydroxypregn-4-Ene-3,20-Dione
CAS No.	600-67-9
Molecular Formula	C21H30O4
Molecular Weight	346.46 g/mol
Synonyms	11α,21-Dihydroxyprogesterone; 11α-Hydroxycortexone; 11α-Hydroxydeoxycorticosterone; 11α,21-Dihydroxy-4-pregnene-3,20-dione; Reichstein's Substance S; 11α-OH-DOC; 11α-Hydroxy-21-deoxycorticosterone; 11α-Hydroxy-21-desoxycorticosterone
EINECS	Contact for details

Quality Control

Our 11α,21-Dihydroxypregn-4-Ene-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of specific impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with the stringent requirements of pharmaceutical ingredient supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.