Description

Phenoxybenzamine Hydrochloride CAS NO 63-92-3 is a potent, irreversible α-adrenergic receptor antagonist. This compound is a critical active pharmaceutical ingredient (API) and research chemical, valued for its specific pharmacological action. It is primarily required by pharmaceutical manufacturers for drug formulation and by research institutions for pharmacological and biochemical studies.

Application

• Pharmaceutical Active Ingredient (API): Core component in the manufacture of medications for the management of pheochromocytoma and other conditions requiring α-blockade.
• Pharmacological Research: Essential tool for studying α-adrenergic receptor mechanisms, signal transduction, and vascular physiology in preclinical models.
• Reference Standard: Used as a high-purity calibrant in analytical laboratories for quality control (QC) and method development in pharmaceutical analysis.
• Biochemical Assay Development: Employed in the design and validation of in vitro assays to screen for adrenergic activity or drug-receptor interactions.
• Academic & Clinical Research: Supports investigative studies in hypertension, autonomic nervous system disorders, and urology.

Basic Information

Product Name	Phenoxybenzamine Hydrochloride
CAS No.	63-92-3
Molecular Formula	C18H22ClNO • HCl
Molecular Weight	340.29 g/mol
Synonyms	Phenoxybenzamine HCl; N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine Hydrochloride; Dibenzyline Hydrochloride; Benzyl(2-chloroethyl)(1-methyl-2-phenoxyethyl)amine Hydrochloride; NSC 35039; BRN 3911325; SKF 688A; PBZ HCl
EINECS	200-570-8

Quality Control

Our Phenoxybenzamine Hydrochloride is manufactured and tested under a strict quality management system. We provide material suitable for pharmaceutical research and development, with specifications that can meet relevant pharmacopeial standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each batch to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity: ≤0.5% Total impurities: ≤2.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.