Description

4-Aminohippuric Acid is a high-purity organic compound, also known as p-Aminohippuric Acid (PAH), serving as a critical intermediate and reference standard in pharmaceutical and diagnostic research. Its primary value lies in its role as a diagnostic agent for measuring renal plasma flow and tubular function. This product is essential for manufacturers and research institutions in the pharmaceutical, biotechnology, and clinical diagnostics sectors. We supply it in various grades to meet diverse application needs, from research and development to commercial production.

Application

• Renal Function Diagnostic Agent: Key active pharmaceutical ingredient (API) in diagnostic kits for measuring effective renal plasma flow (ERPF) and para-aminohippurate (PAH) clearance tests.
• Pharmaceutical Intermediate: Used in the synthesis of more complex pharmaceutical compounds and contrast agents.
• Biochemical Research: Employed as a substrate or inhibitor in studies of organic anion transporters (OATs) in renal physiology and pharmacology.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in laboratories.
• Metabolite Studies: Utilized in metabolic pathway research and as a marker in pharmacokinetic studies.

Basic Information

Product Name	4-Aminohippuric Acid
CAS No.	61-78-9
Molecular Formula	C9H10N2O3
Molecular Weight	194.19 g/mol
Synonyms	p-Aminohippuric Acid; PAH; N-(4-Aminobenzoyl)glycine; 4-Aminobenzoylglycine; 4-Amino-N-(carboxymethyl)benzamide; Hippuran (related to diagnostic use); Para-aminohippurate; 61-78-9; NSC 4911
EINECS	200-517-6

Quality Control

Our 4-Aminohippuric Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical and diagnostic applications. We provide Certificates of Analysis (COA) with detailed results for parameters including assay, related substances, and identification. Our quality commitment aligns with cGMP principles, and we can support regulatory filings as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed after opening to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.