Description

Methimazole CAS NO 60-56-0 is a thioamide derivative that acts as a potent and specific inhibitor of thyroid peroxidase, the enzyme responsible for thyroid hormone synthesis. This mechanism of action makes it a critical active pharmaceutical ingredient (API) for managing hyperthyroidism, including Graves' disease. It is essential for pharmaceutical manufacturers producing anti-thyroid medications, as well as for research institutions studying thyroid function and hormone regulation.

Application

• Primary Pharmaceutical Ingredient: The principal active component in oral medications for the treatment of hyperthyroidism and thyrotoxicosis.
• Veterinary Medicine: Used in the management of feline hyperthyroidism, a common endocrine disorder in older cats.
• Biochemical Research: A vital tool for in vitro and in vivo studies to induce hypothyroid conditions and investigate thyroid hormone pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control testing in pharmaceutical laboratories.
• Preclinical Studies: Employed in animal models to study the effects of thyroid hormone modulation on metabolism, development, and other physiological processes.

Basic Information

Product Name	Methimazole
CAS No.	60-56-0
Molecular Formula	C4H6N2S
Molecular Weight	114.17 g/mol
Synonyms	1-Methyl-2-imidazolethiol; 1-Methyl-2-mercaptoimidazole; Thiamazole; Tapazole; Mercazolyl; Methimazol; Mercaptizol; Favisran; Thyrozol; Metizol
EINECS	200-482-4

Quality Control

Our Methimazole is manufactured under strict quality management systems. It undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with each batch to guarantee traceability and compliance with relevant pharmacopoeial standards (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	98.0% - 102.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.