Description

Guanethidine Hemisulfate is a high-purity pharmaceutical intermediate and research chemical. This compound is a potent and selective adrenergic neuron blocking agent, historically significant in cardiovascular research and pharmacology. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of fine chemicals for the development and synthesis of specialized therapeutic agents.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel adrenergic agents and for pharmacological studies.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development and validation.
• Biochemical Research: Employed in neuroscience and autonomic nervous system studies to investigate noradrenaline release and sympathetic nerve function.
• Fine Chemical Synthesis: Serves as a building block for the preparation of more complex, specialized chemical entities.
• Academic Studies: Utilized in university and institutional research for teaching and experimental purposes related to cardiovascular and neuropharmacology.

Basic Information

Product Name	Guanethidine Hemisulfate
CAS No.	60-02-6
Molecular Formula	C10H22N4 • 1/2H2SO4
Molecular Weight	246.33 g/mol (free base: 198.31)
Synonyms	Guanethidine Monosulfate; Guanethidine Sulfate (1:1); (2-Hexahydro-1(2H)-azocinyl)ethyl]guanidine sulfate; Ismelin Sulfate; Abapressin; Iporal; Octadine Sulfate; Antipres; Visutensil
EINECS	200-458-8

Quality Control

Our Guanethidine Hemisulfate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including identification, purity assay, and impurity profiling to ensure it meets stringent specifications for research and pharmaceutical use. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.