Description

4-(Difluoromethyl)-n-Hydroxybenzimidoyl Chloride is a specialized benzimidoyl chloride derivative featuring a difluoromethyl substituent, a key reactive intermediate in modern synthetic chemistry. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing heterocyclic cores and introducing fluorinated motifs.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those targeting kinase inhibition or requiring fluorinated bioactive molecules.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the difluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Chemical Research & Development: An essential reagent for method development and exploring new reactions in academic and industrial research laboratories.
• Fluorinated Compound Library Synthesis: Key for creating diverse libraries of fluorinated compounds for high-throughput screening in drug discovery programs.

Basic Information

Product Name	4-(Difluoromethyl)-n-Hydroxybenzimidoyl Chloride
CAS No.	596095-16-8
Molecular Formula	C8H5ClF2NO
Molecular Weight	204.58 g/mol
Synonyms	4-(Difluoromethyl)benzohydroximoyl Chloride; N-Hydroxy-4-(difluoromethyl)benzimidoyl Chloride; 4-(Difluoromethyl)-N-hydroxybenzenecarboximidoyl Chloride; 4-(Difluoromethyl)benzohydroxamic Acid Chloride; Benzenecarboximidoyl Chloride, N-hydroxy-4-(difluoromethyl)-; 4-(Difluoromethyl)benzohydroxamoyl Chloride
EINECS	Contact for details

Quality Control

Every batch of 4-(Difluoromethyl)-n-Hydroxybenzimidoyl Chloride is manufactured and tested under strict quality management systems. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, NMR, and FTIR, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.