Description

Rigosertib Sodium CAS NO 592542-60-4 is a potent and selective small-molecule inhibitor of the PI3K and PLK1 signaling pathways. This compound is of significant value in oncology research for its ability to induce cell cycle arrest and apoptosis in cancer cells. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in the development of novel cancer therapeutics, particularly for myelodysplastic syndromes (MDS) and other solid tumors.

Application

• Oncology Research & Drug Discovery: A key investigational agent for studying cell cycle regulation, apoptosis, and signal transduction pathways in cancer biology.
• Preclinical Development: Used in in vitro and in vivo studies to evaluate efficacy, pharmacokinetics, and toxicology profiles for potential cancer treatments.
• Biochemical Assays: Serves as a critical reference standard and tool compound in high-throughput screening and target validation assays.
• Mechanistic Studies: Employed to investigate the roles of PI3K and PLK1 pathways in various disease models beyond oncology.
• Pharmaceutical Intermediates: Can be utilized in the synthesis of more complex molecular entities or prodrug formulations.
• Reference Standard: Essential for analytical method development, validation, and quality control in regulatory submissions for clinical trials.

Basic Information

Product Name	Rigosertib Sodium
CAS No.	592542-60-4
Molecular Formula	C21H20N3NaO6
Molecular Weight	433.39 g/mol
Synonyms	ON 01910.Na; Rigosertib sodium salt; (E)-N-((2-Methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)carbonyl)-4-methylbenzenesulfonamide sodium salt; ON01910 sodium salt; TAS-116 sodium; ON-01910Na; Sodium rigosertib
EINECS	Contact for details

Quality Control

Our Rigosertib Sodium is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and development standards. We support our clients with the documentation necessary for preclinical and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm
Assay (on anhydrous basis)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.