Description

N6-Me-Ra Phosphoramidite CAS NO 588698-79-7 is a specialized, high-purity phosphoramidite monomer used in the automated solid-phase synthesis of oligonucleotides. This compound is critical for introducing site-specific modifications into DNA or RNA strands, enabling advanced research and therapeutic development. It is an essential reagent for biotechnology, pharmaceutical, and diagnostic companies focused on nucleic acid chemistry, antisense technology, and the development of oligonucleotide-based therapeutics.

Application

• Oligonucleotide Synthesis: Key building block for the automated solid-phase synthesis of modified DNA and RNA sequences.
• Antisense & siRNA Development: Used to create research-grade and therapeutic oligonucleotides with enhanced stability and target specificity.
• Diagnostic Probe Manufacturing: Enables the production of labeled probes for genetic testing, FISH, and microarray applications.
• Structural Biology Studies: Facilitates the incorporation of specific modifications to study nucleic acid structure, function, and protein interactions.
• Aptamer Discovery: Essential for generating libraries of modified aptamers with improved binding affinity and nuclease resistance.
• Pharmaceutical R&D: Supports the discovery and preclinical development of novel oligonucleotide drugs.

Basic Information

Product Name	N6-Me-Ra Phosphoramidite
CAS No.	588698-79-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	6-N-Methyladenosine Phosphoramidite; 6-N-Methyl-A Phosphoramidite; N6-Methyladenosine 2'-Deoxyriboside Phosphoramidite; 2'-Deoxy-N6-methyladenosine Phosphoramidite; 5'-Dimethoxytrityl-N6-methyl-2'-deoxyadenosine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; dA(6-Me) Phosphoramidite; N6-Me-dA Phosphoramidite
EINECS	Contact for details

Quality Control

Every batch of N6-Me-Ra Phosphoramidite is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and performance consistency. Our products are suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (HPLC), identity (NMR, MS), and moisture content is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.