Description

5'-o-(Dimethoxytrityl)-5-Iodo-2'-o-Methyluridine is a key protected nucleoside derivative used as a critical building block in oligonucleotide synthesis. This compound is specifically engineered to introduce modified bases into synthetic DNA or RNA strands, enabling advanced research in molecular biology and therapeutic development. It is an essential raw material for pharmaceutical R&D, diagnostic assay developers, and academic institutions focused on antisense technology, siRNA, and aptamer development.

Application

• Oligonucleotide Synthesis: A vital phosphoramidite precursor for the solid-phase synthesis of modified oligonucleotides.
• Antisense & RNAi Therapeutics: Used to incorporate 5-iodouridine analogs into siRNA or antisense oligonucleotides for enhanced stability and target binding.
• Diagnostic Probe Development: Enables the creation of labeled nucleic acid probes for detection and diagnostic applications.
• Structural Biology Studies: Facilitates the study of nucleic acid structure and function through site-specific modification.
• Medicinal Chemistry: Serves as an intermediate in the development of nucleoside-based antiviral and anticancer agents.
• Bioconjugation: The iodine moiety provides a handle for further functionalization via cross-coupling reactions (e.g., Sonogashira, Suzuki).

Basic Information

Product Name	5'-o-(Dimethoxytrityl)-5-Iodo-2'-o-Methyluridine
CAS No.	588691-24-1
Molecular Formula	C31H31IN2O7
Molecular Weight	670.50 g/mol
Synonyms	5'-O-DMT-5-Iodo-2'-O-methyluridine; 5-Iodo-2'-O-methyl-5'-O-(4,4'-dimethoxytrityl)uridine; 5-Iodo-2'-O-methyluridine 5'-O-DMT; 1-[(2R,3R,4R,5R)-5-[Bis(4-methoxyphenyl)(phenyl)methoxy]-4-hydroxy-2-(hydroxymethyl)-3-methoxyoxolan-2-yl]-5-iodopyrimidine-2,4-dione; DMT-5-I-2'-OMe-U
EINECS	Contact for details

Quality Control

Our 5'-o-(Dimethoxytrityl)-5-Iodo-2'-o-Methyluridine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. All products undergo rigorous analytical testing including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.