Description

Imatinib Usp Guanidine Analog is a high-purity pharmaceutical intermediate and reference standard, specifically a guanidine-based analog of the well-known tyrosine kinase inhibitor Imatinib. This compound is critical for research and development in medicinal chemistry, particularly for the synthesis and analytical validation of novel kinase-targeted therapeutics. It serves the needs of pharmaceutical R&D laboratories, academic research institutions, and quality control departments requiring precise chemical building blocks for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research-scale production of novel Imatinib derivatives and related kinase inhibitors.
• Analytical Reference Standard: Used for method development, validation, and quality control (HPLC, LC-MS) in pharmaceutical analysis to ensure product purity and identity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the impact of guanidine moiety modifications on biological activity and selectivity.
• Biochemical Research: Utilized as a tool compound in enzymatic assays to study kinase inhibition mechanisms and off-target effects.
• Process Development: Serves as a model compound for optimizing synthetic routes, purification processes, and crystallization studies in API manufacturing.

Basic Information

Product Name	Imatinib Usp Guanidine Analog
CAS No.	581076-67-7
Molecular Formula	C30H35N7O
Molecular Weight	509.65 g/mol
Synonyms	4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide guanidine analog; Imatinib Guanidine Derivative; STI-571 Guanidine Analog; Gleevec Guanidine Analog; CGP 57148B Guanidine Analog; N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)pyrimidin-2-amine-4-[(4-methylpiperazin-1-yl)methyl]benzamide guanidine analog; 581076-67-7
EINECS	Contact for details

Quality Control

Our Imatinib Usp Guanidine Analog is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development protocols. Our commitment to consistent high purity supports reliable and reproducible scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.