Description

Benzamide, 4-(Dichloromethyl)-n-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]- is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure. This compound is critical for the synthesis of targeted therapeutic agents, particularly in oncology research and development. It is essential for pharmaceutical manufacturers and research institutions engaged in the development of novel kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of targeted cancer therapies and kinase inhibitors.
• Oncology Research: Used in preclinical and clinical research for developing novel anti-cancer compounds.
• Chemical Biology: Serves as a probe or precursor in studying enzyme inhibition and signal transduction pathways.
• Process Development: Employed in scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs).
• Custom Synthesis: Starting material for the preparation of specialized analogs and derivatives for structure-activity relationship (SAR) studies.

Basic Information

Product Name	Benzamide, 4-(Dichloromethyl)-n-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-
CAS No.	581076-66-6
Molecular Formula	C24H19Cl2N5O
Molecular Weight	464.35 g/mol
Synonyms	4-(Dichloromethyl)-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide; N-(4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(dichloromethyl)benzamide; Imatinib Intermediate; Gleevec Intermediate; STI-571 Intermediate; Bcr-Abl Kinase Inhibitor Intermediate; 581076-66-6; 4-(Dichloromethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
EINECS	Contact for details

Quality Control

Our production of Benzamide, 4-(Dichloromethyl)-n-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]- adheres to stringent quality management systems suitable for pharmaceutical applications. All batches undergo comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.