Description

Benzenemethanol, 3,5-Difluoro-α-Methyl-, (-)- (9Ci) is a chiral, fluorinated benzyl alcohol derivative of significant interest in advanced organic synthesis. This compound matters as a high-value building block for creating complex molecules with precise stereochemistry and enhanced physicochemical properties. Pharmaceutical and agrochemical R&D teams need it for developing novel active ingredients, particularly where the introduction of fluorine atoms and a defined chiral center is critical for bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the fluorinated aromatic system can improve lipophilicity and target binding.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, enabling highly enantioselective transformations.
• Material Science Research: Employed in the synthesis of specialty monomers and polymers where fluorine incorporation can alter surface energy and stability.
• Fluorine Chemistry Studies: A valuable reference compound and starting material for academic and industrial research into the effects of aromatic fluorine substitution.

Basic Information

Product Name	Benzenemethanol, 3,5-Difluoro-α-Methyl-, (-)- (9Ci)
CAS No.	575488-42-5
Molecular Formula	C8H8F2O
Molecular Weight	158.15 g/mol
Synonyms	(-)-3,5-Difluoro-α-methylbenzyl alcohol; (S)-1-(3,5-Difluorophenyl)ethanol; (1S)-1-(3,5-Difluorophenyl)ethan-1-ol; 3,5-Difluoro-α-methylbenzyl alcohol, (-)-; α-Methyl-3,5-difluorobenzyl alcohol, (S)-; 575488-42-5; (S)-(-)-1-(3,5-Difluorophenyl)ethanol
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management protocols. Each batch is characterized using advanced analytical techniques including chiral HPLC, GC, NMR, and MS to ensure high enantiomeric excess (ee) and chemical purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.