Description

Palbociclib CAS NO 571190-30-2 is a highly potent and selective small-molecule inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). This compound is of critical importance in the field of oncology research and pharmaceutical development, specifically targeting the cell cycle progression of cancer cells. It is an essential active pharmaceutical ingredient (API) and key intermediate for research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in developing and producing advanced cancer therapeutics, particularly for hormone receptor-positive (HR+) breast cancer.

Application

• Primary Active Pharmaceutical Ingredient (API) for the formulation of oral anti-cancer medications.
• Critical reference standard and impurity marker in pharmaceutical quality control and analytical laboratories.
• Key intermediate in the synthesis of novel CDK4/6 inhibitor derivatives and prodrugs for research purposes.
• Essential biochemical tool for in vitro and in vivo cancer research, studying cell cycle regulation and drug resistance mechanisms.
• Used in preclinical and clinical development studies for oncology drug candidates.
• Raw material for the preparation of calibration standards in bioanalytical method development (e.g., LC-MS/MS).

Basic Information

Product Name	Palbociclib
CAS No.	571190-30-2
Molecular Formula	C24H29N7O2
Molecular Weight	447.54 g/mol
Synonyms	PD-0332991; Ibrance (Trade Name); 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one; (S)-6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one; CDK4/6 Inhibitor; PD0332991
EINECS	Contact for details

Quality Control

Our Palbociclib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.