Description

3'-β-C-Ethynyl-N6,N6-Dimethyladenosine is a chemically modified nucleoside analog, a key building block in medicinal chemistry and pharmaceutical research. Its unique structure, featuring an ethynyl group at the 3' position and dimethylation at the N6 adenine position, makes it a valuable intermediate for developing novel therapeutics and biochemical probes. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in antiviral drug discovery, oligonucleotide synthesis, and the development of enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Biochemical Research: Used as a modified substrate or probe to study enzyme kinetics, particularly adenosine-modifying enzymes and polymerases.
• Oligonucleotide Synthesis: Serves as a specialty phosphoramidite or solid-support building block for creating modified DNA/RNA strands with enhanced properties.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize drug potency, selectivity, and metabolic stability.
• Chemical Biology Tool: Utilized for labeling or cross-linking applications due to the reactive ethynyl group, enabling "click chemistry" conjugation.

Basic Information

Product Name	3'-β-C-Ethynyl-N6,N6-Dimethyladenosine
CAS No.	565450-82-0
Molecular Formula	C14H16N6O4
Molecular Weight	332.32 g/mol
Synonyms	3'-C-Ethynyl-N6,N6-dimethyladenosine; 3'-β-C-Ethynyl-N6,N6-dimethyladenosine; 1-(3-Deoxy-3-C-ethynyl-β-D-ribofuranosyl)-N6,N6-dimethyladenine; N6,N6-Dimethyl-3'-C-ethynyladenosine; 3'-Ethynyl-N6,N6-dimethyladenosine; 3'-C-Ethynyl-N6,N6-dimethyl-9H-purin-6-amine riboside
EINECS	Contact for details

Quality Control

Our 3'-β-C-Ethynyl-N6,N6-Dimethyladenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.