Description

Sunitinib CAS NO 557795-19-4 is a small molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor with potent antitumor and antiangiogenic activity. This high-purity active pharmaceutical ingredient (API) is critical for the development and manufacturing of targeted cancer therapies. It is primarily required by pharmaceutical companies and advanced research institutions engaged in oncology drug development, clinical trials, and the production of finished dosage forms.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of targeted anti-cancer medications.
• Oncology Research: Used in preclinical and clinical studies to investigate mechanisms of action and therapeutic efficacy against various cancers.
• Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control testing in laboratories.
• Drug Development Intermediates: Utilized in the synthesis and process development of novel kinase inhibitor derivatives.
• Biochemical Research: A tool compound for studying signal transduction pathways involving PDGFR, VEGFR, KIT, and other related kinases.

Basic Information

Product Name	Sunitinib
CAS No.	557795-19-4
Molecular Formula	C₂₂H₂₇FN₄O₂
Molecular Weight	398.47 g/mol
Synonyms	Sunitinib Malate; SU11248; Sunitinib Base; N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide; Sutent (brand name); SU 11248; Sunitinib (free base)
EINECS	Contact for details

Quality Control

Our Sunitinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent purity and identity criteria, typical for pharmaceutical-grade APIs. We provide full traceability and support regulatory submissions. Certificates of Analysis (COA) detailing purity, related substances, residual solvents, and other critical parameters are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.