Description

Cdk4 Inhibitor CAS NO 546102-60-7 is a potent and selective small molecule inhibitor of cyclin-dependent kinase 4 (CDK4), a key regulator of the cell cycle. This compound is a critical research tool for investigating cell cycle progression, cellular proliferation, and the development of targeted cancer therapies. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on oncology and molecular biology.

Application

• Oncology Research: Used as a biochemical tool to study the role of the CDK4/cyclin D1 pathway in cancer cell proliferation and tumorigenesis.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of novel CDK4-targeted anticancer agents.
• Cell Cycle Analysis: Employed in in vitro and cell-based assays to induce G1 phase cell cycle arrest and study checkpoint mechanisms.
• Mechanistic Studies: Facilitates research into cellular senescence, apoptosis, and the therapeutic potential of CDK4 inhibition in various cancer types.
• Biochemical Assay Development: Acts as a key component in high-throughput screening (HTS) campaigns to identify and validate new CDK4 inhibitors.

Basic Information

Product Name	Cdk4 Inhibitor
CAS No.	546102-60-7
Molecular Formula	C₂₂H₂₈N₈O₂S
Molecular Weight	468.58 g/mol
Synonyms	PD 0332991; Palbociclib (Isethionate); PD-0332991 Isethionate; Ibrance (Isethionate Salt); 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one 2-hydroxyethanesulfonate; LEE011 (Related compound); CDK4/6 Inhibitor.
EINECS	Contact for details

Quality Control

Our Cdk4 Inhibitor is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing identity, purity, and strength is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. The material is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.