Description

2'-o-Methoxyethyl Inosine is a chemically modified nucleoside analog, specifically an inosine derivative with a 2'-O-methoxyethyl (MOE) substitution. This modification is critical for enhancing the binding affinity, nuclease resistance, and pharmacokinetic profile of oligonucleotide therapeutics. It serves as a key building block in the synthesis of advanced antisense oligonucleotides (ASOs) and other RNA-targeting drugs. This high-purity intermediate is essential for pharmaceutical R&D and manufacturing, particularly for companies developing treatments for genetic disorders, cancers, and viral infections.

Application

• Antisense Oligonucleotide (ASO) Synthesis: Primary building block for constructing therapeutic ASOs with improved stability and target engagement.
• RNA Therapeutics R&D: Used in research and development of siRNA, aptamers, and other RNA-based modalities.
• Pharmaceutical Intermediates: Serves as a critical raw material in the cGMP production of nucleotide-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Valuable tool for studying RNA structure, function, and protein-RNA interactions in academic and industrial laboratories.
• Diagnostic Probe Development: Utilized in the design of high-specificity probes for genetic testing and molecular diagnostics.

Basic Information

Product Name	2'-o-Methoxyethyl Inosine
CAS No.	545374-76-3
Molecular Formula	C12H18N4O6
Molecular Weight	314.29 g/mol
Synonyms	2'-O-MOE-Inosine; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-3H-purin-6-one; 2'-O-(2-Methoxyethyl)inosine; Inosine, 2'-O-(2-methoxyethyl)-; MOE-Inosine; 2'-MOE-Inosine; 2'-O-Methoxyethylinosine
EINECS	Contact for details

Quality Control

Our 2'-o-Methoxyethyl Inosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture. We provide full traceability and Certificates of Analysis (COA) are available for every shipment. The product is suitable for use in GMP environments, supporting the highest standards required for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.