Description

Benzenepropanoyl Chloride, 4-(Trifluoromethyl)- is a high-value organic intermediate characterized by its reactive acid chloride functional group and a trifluoromethyl-substituted aromatic ring. This compound is essential for introducing the 4-(trifluoromethyl)hydrocinnamoyl moiety into target molecules, a modification known to enhance metabolic stability and lipophilicity in advanced chemical synthesis. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the production of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a critical monomer for creating fluorinated aromatic components in electronic display and lighting materials.
• Peptide Mimetics & Bioconjugation: Employed in medicinal chemistry to create hydrocarbon-stapled peptides or to conjugate small molecules to proteins and other biomolecules.
• Polymer Modification: Acts as a grafting agent to introduce functional aromatic side chains into polymer backbones, altering material properties.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	Benzenepropanoyl Chloride, 4-(Trifluoromethyl)-
CAS No.	539855-79-3
Molecular Formula	C10H8ClF3O
Molecular Weight	236.62 g/mol
Synonyms	4-(Trifluoromethyl)hydrocinnamoyl chloride; 3-[4-(Trifluoromethyl)phenyl]propionyl chloride; 3-(4-Trifluoromethylphenyl)propanoic acid chloride; 4-(Trifluoromethyl)benzenepropanoyl chloride; γ-(4-Trifluoromethylphenyl)propionyl chloride; (4-Trifluoromethylphenyl)propionic acid chloride; 3-(4-Trifluoromethylphenyl)propanoyl chloride
EINECS	Contact for details

Quality Control

Every batch of Benzenepropanoyl Chloride, 4-(Trifluoromethyl)- is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by GC/HPLC), identity (IR, NMR), and impurity profiles. Our quality commitment supports compliance with cGMP and ISO 9001 standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.